Packet 1: Bonus 1

Phenyl iso·thio·cyanate is converted to phenylthiohydantoin (“phenyl-thio-hy-DAN-toh-in”) in a method for this task named for a Swedish chemist. For 10 points each:
[10m] Name this task that can be performed with the now-outdated Edman degradation. Tandem mass spectrometry is commonly used in “top-down” and “bottom-up” approaches to this task.
ANSWER: protein sequencing [or polypeptide sequencing; accept descriptions of determining amino acid order in a protein; prompt on sequencing]
[10h] Protein sequencing via the Edman degradation does not work if the N-terminus is modified, such as the addition of these lipids onto a glycine residue via NMTs, during which they adopt a question-mark-shaped conformation. The name of these lipids is derived from the Latin name of nutmeg.
ANSWER: myristoyl (“my-RIST-oil”) groups [or myristic acid or myristate; accept tetradecanoic acid or tetradecanoyl]
[10e] Dyes exhibiting this phenomenon label amino acids in the Edman degradation. In this phenomenon, a molecule absorbs and reemits light at a longer wavelength on a shorter timescale than phosphorescence.
ANSWER: fluorescence
<Waterloo, Chemistry> | A. Prelims 1 - Waterloo + Toronto A + Georgia Tech B

HeardPPBE %M %H %
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