Packet 5: Bonus 8

Changes in one quantity during this process are calculated as the sum of electrostatic interactions, dispersion-repulsion, and cavitation in polarizable continuum models. For 10 points each:
[10m] Name this process described by “implicit” models like COSMO and the generalized Born model.
ANSWER: solvation [or dissolving or dissolution or forming a solution]
[10e] Implicit models calculate changes in this quantity during solvation, which is thermodynamically favored when it lowers this quantity. This quantity equals enthalpy minus the product of temperature and entropy.
ANSWER: Gibbs free energy [accept Gibbs energy; prompt on free energy or G]
[10h] Implicit solvation models based on a dielectric “continuum” are faster to compute than models based on this quantity. This quantity can be calculated by solving a two-body system in the LCPO method.
ANSWER: accessible surface area [or solvent-accessible surface area or ASA or SASA; accept Lee–Richards molecular surface area; prompt on surface area]
<Editors, Chemistry> | N. Playoffs 5 (Editors 5)

HeardPPBE %M %H %
2413.75100%33%4%

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