Packet 6: Tossup 4

This chemical’s effects are partially mediated by downstream inhibition of Piezo channels via PIP2 depletion. The Y511A mutation abolishes the binding of this compound to the S3 helix of its receptor, which also binds double-knot toxin and resiniferatoxin. A M579T mutation in tree shrews makes them insensitive to this compound. Acetonitrile is used in an HPLC assay in which the peak area of this substance is added to 0.82 times the peak area of its dihydro- derivative, then normalized to give ppmH. (-5[1])Via calpain-dependent ablation of axon terminals, postherpetic neuralgia is treated using an 8-percent patch of this (10[1])compound. (-5[1])Noxious heat and this (10[1])compound activate the vanilloid (10[1])receptor TRPV1. (10[3])Birds and naked (10[1])mole rats (10[1])are immune (10[3])to this (-5[1])Substance (10[1])P agonist. For 10 points, what chemical’s concentration is measured using Scoville (10[2])units? (10[1])■END■ (10[5]0[1])

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