Packet 5: Tossup 5

A mutation in SLC25A1, which encodes a carrier for this compound, causes combined D,L-2-hydroxy·glutaric aciduria. A methyl derivative of this compound names a biochemical pathway that breaks down toxic propionyl-CoA generated via beta-oxidation. This compound allosterically activates the carboxylation of acetyl-CoA to malonyl-CoA during fatty acid biosynthesis. A namesake lyase cleaves an isomer (10[1])of this compound to form (10[1])glyoxylate in the glyoxylate cycle. (10[1])Along with PEP and ATP, this compound stabilizes the inactive T-state of PFK-1. The isomerization of this compound (10[1])is (10[1])catalyzed by aconitase (10[4])(“uh-CON-ih-tase”). This compound is (-5[1])formed after acetyl-CoA, (10[2])generated from (10[1])pyruvate, (10[1])combines with oxalo·acetate. (10[3])For 10 points, (10[1])name this tricarboxylic (10[1])acid that names the Krebs (10[1])cycle. (10[1])■END■ (0[1])

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