Packet 3: Tossup 18

Congenital defects in enzymes localizing to this organelle cause a type II pattern in a CDT assay. A process primarily occurring in this organelle uses four “major” and four “minor” core structures. In this organelle, the enzymes FUT2 and FUT3 (-5[1])create the Lewis secretor phenotype, and the H antigen is elaborated into the A or B antigens. In this organelle, a nearby proline often determines sites of its mucin-type modifications to serine and threonine residues. (10[2])By inhibiting the nucleotide exchange (10[1])factor GBF1 and thus inhibiting Arf1p, brefeldin A (10[1]-5[1])causes (10[1])this (10[1])organelle (10[1])to disappear (-5[1])by inhibiting (10[1])COPI (10[1])(“cop-one”) trafficking. (10[2]-5[1])This organelle (10[1])adds mannose-6-phosphate (10[3])to lysosomal (-5[1])hydrolases and operates via cisternal maturation across cis, medial, (10[1])and trans portions. For 10 points, name this stack of flattened cisternae that packages (10[1])and sorts proteins. (10[1])■END■ (10[3])

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