Packet 8: Tossup 1

These cells specifically express the L7/pcp2 promoter. Mutating the Grid2 gene in mice produces the Lurcher phenotype by killing these cells, which are organized in longitudinal stripes that stain with zebrin II. The loss of these cells drives a condition caused by repeat expansions in CACNA1A (“CACK-nuh-one-A”) or ATXN1 (“ataxin-one”). CDR2 in these cells is targeted by anti-Yo antibodies (-5[1])in a form of paraneoplastic degeneration. (10[1])In this subclass of cells, parallel fibers drive simple spikes and conjunctive long-term depression, (-5[1])while climbing fibers from the (10[1])superior olive (-5[1])evoke complex spikes. Like pyramidal cells, these highly-branched (10[1])neurons were imaged by Santiago Ramón y Cajal (-5[3])(“ka-HALL”) using (-5[1])a Golgi stain. (-5[1])For 10 points, (-5[1])name these neurons with prominent (10[1])dendritic (10[1])arbors in the cerebellum, (10[1])named for a Czech (10[2])physiologist (10[2]-5[1])who also names conducting fibers (10[1])in the heart. ■END■ (10[13]0[1])

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