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Packet 5: Bonus 16

Repertoire freeze is a manifestation of this phenomenon. For 10 points each:
[10h] What idea in immunology states that the memory response is based on the initial encounter with a pathogen when challenged with a new strain? It is also called immunological or antigenic imprinting.
ANSWER: original antigenic sin [or Hoskins effect or primary addiction; prompt on OAS]
[10e] Thomas Francis Jr. coined the term “original antigenic sin” while studying responses to this respiratory virus. The hemagglutinin and neuraminidase surface proteins of this virus name strains of it like H1N1 and H5N1.
ANSWER: influenza [or flu]
[10m] An example of OAS is the response to one of the four serotypes of this virus, after which infection with another strain causes hemorrhagic fever via antibody-dependent enhancement. This flavivirus is carried by Aedes aegypti.
ANSWER: Dengue fever [or Dengue virus or DENV]
<Editors, Biology> | N. Playoffs 5 (Editors 5)

HeardPPBE %M %H %
1813.33100%33%0%

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Conversion

TeamOpponentPart 1Part 2Part 3TotalParts
CambridgeIllinois A0101020EM
Chicago AIndiana010010E
Chicago BMaryland B010010E
Columbia AVirginia Tech0101020EM
GeorgetownWaterloo010010E
Georgia Tech AColumbia B0101020EM
HarvardUC Berkeley B0101020EM
MITWashU010010E
NYU BMichigan010010E
Northwestern AMaryland A0101020EM
Penn StateRutgers010010E
PittsburghGeorgia Tech C010010E
PurdueUCF010010E
Toronto AStanford A010010E
Toronto BMinnesota010010E
UC Berkeley ANYU A010010E
UCLABritish Columbia010010E
VanderbiltTexas0101020EM

Summary

TournamentEditionMatchHeardPPBE %M %H %
Main Site2026-04-17✓1813.33100%33%0%