Packet 5: Bonus 8

The rotund gene belongs to a family of transcription factors named after this gene. For 10 points each:
[10h] Name this gap gene expressed in a stripe at the center of the anterior–posterior axis. This gene names a family of, quote, “like” factors that includes the only Yamanaka factor with a zinc-finger motif.
ANSWER: Krüppel [accept Krüppel-like factor; prompt on KLF4]
[10e] The Yamanaka factors can reprogram differentiated cells into ones with the “induced” version of this potency. Stem cells of this potency can become cells of the ectoderm, mesoderm, and endoderm, but not of extra-embryonic tissue.
ANSWER: pluripotent [or pluripotency; accept induced pluripotent stem cells; prompt on iPSC]
[10m] Yamanaka’s original iPS cells were derived from the embryonic type of these cells in mice. These cells synthesize and secrete collagen.
ANSWER: fibroblasts [or mouse embryonic fibroblasts; prompt on MEF]
<MIT, Biology> | E. Prelims 5 - Indiana + Vanderbilt + MIT

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