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Packet 8: Bonus 11

This broad set of genetic disorders causes progressive night blindness with ring scotomas, an extinguished ERG, and bone-spicule pigmentation with attenuated arterioles. For 10 points each:
[10h] Name this genetically heterogeneous cause of vision loss. The first FDA-approved AAV-based gene therapy, Luxturna, treats one form of this disease called Leber congenital amaurosis.
ANSWER: retinitis pigmentosa [or RP; prompt on inherited retinal dystrophy or IRD]
[10e] A palmitate derivative of this fat-soluble vitamin can slow loss of vision in retinitis pigmentosa. A derivative of this vitamin, retinal (“RET-in-AL”), is a cofactor for opsins.
ANSWER: vitamin A
[10m] PRPF31-associated autosomal-dominant RP is an example of this genetic phenomenon in which not all holders of a mutation show the corresponding phenotype. The blue sclera trait also displays this phenomenon.
ANSWER: incomplete penetrance [or reduced penetrance; prompt on penetrance]
<Editors, Biology> | H. Prelims 8 - Stanford A + Georgia Tech C + Columbia A + Columbia B

HeardPPBE %M %H %
209.0080%10%0%

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Conversion

TeamOpponentPart 1Part 2Part 3TotalParts
British ColumbiaCambridge010010E
BruinMichigan010010E
Chicago BIllinois B010010E
GeorgetownSwarthmore0000
Georgia Tech ATexas010010E
Georgia Tech BToronto A010010E
HarvardOhio State010010E
IndianaWaterloo010010E
Maryland ANYU B010010E
MinnesotaPurdue0000
North CarolinaRutgers010010E
Penn StateVirginia Tech0000
PittsburghMIT010010E
Stanford BIllinois A010010E
Toronto BNorthwestern A0101020EM
UC Berkeley AVirginia010010E
UC Berkeley BBrown0101020EM
UCLAMaryland B010010E
VanderbiltNorthwestern B0000
WashUChicago A010010E

Summary

TournamentEditionMatchHeardPPBE %M %H %
Main Site2026-04-17✓209.0080%10%0%