Round 18: Tossup 20

Yang et al. found that levels of this protein and its receptor are overexpressed in the area postrema in area postrema syndrome. Drugs that inhibit an enzyme that cuts this protein between Ala-8 and Glu-9 are a common cause of drug-induced bullous pemphigoid. This protein is cleaved from a precursor where it is adjacent to oxyntomodulin and intervening peptide 2. John Eng isolated an analog of this protein from Gila monster saliva. (10[1]-5[2])This protein (10[1]-5[1])is cleaved (10[1])by proconvertase (10[1])1 and 3 into its active 7-37 form in (10[1])enteroendocrine L cells. Exenatide mimics this protein, (10[2])which like (-5[1])GIP (-5[2])is cleaved by DPP4. Both GIP and this protein’s receptor are agonized by tirzepatide. (-5[1])This incretin’s receptor (10[1])is selectively inhibited by semaglutide, (10[1]-5[1])or (-5[1])Ozempic. (10[1]-5[1])For 10 (-5[1])points, (-5[1])name this protein whose receptor is targeted by a class of anti-obesity medications. ■END■ (10[6]0[6])

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Summary