Round 20: Tossup 2
These cells are targeted by tagmokitug, an anti-CCR8 antibody. These cells’ proliferation is enhanced by CD39 and CD73 converting ATP to adenosine. These cells are upregulated by the activity of IDO1 in APCs. The Scurfy mouse has a mutation in a transcription factor controlling these cells’ development, which is mutated in a disease characterized by the triad of eczema, enteropathy, and endocrinopathy called IPEX syndrome. Flow cytometric markers for these cells include GITR, CD25 and CTLA-4. These cells develop from precursors expressing intermediate-affinity TCRs under TGF-beta control, which skews them away from the Th17 lineage by increasing Foxp3 expression. For 10 points, Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi won the 2025 Nobel Prize for describing what subset of T cells that dampen overactive immune responses? ■END■
ANSWER: regulatory T cells [or Treg; accept suppressor T cells; prompt on T cells or CD4+ T cells or lymphocytes or tumor-infiltrating lymphocytes or TIL or white blood cells or WBC ]
<Editors, Biology> | U. Finals 1 (Editors 11)
= Average correct buzzpoint
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