Round 8: Tossup 13

Group 4A of these enzymes are inhibited by 2-oxo-amides. In a type of snake venom, the chaperone crotapotin binds one of these enzymes to form crotoxin. Brown recluse spiders produce the “D” type of these enzymes as their primary venom. A receptor for one of these enzymes is targeted by autoantibodies in membranous glomerulonephritis. A zinc-dependent one of these enzymes is the catalytic component of Clostridium perfringens alpha toxin, which causes myonecrosis and gas gangrene. The A2 type of these enzymes produces arachidonic (10[1])acid, (10[1])a prostaglandin (10[1])and (10[1])leukotriene (-5[1])precursor. PIP2 is (-5[1])cleaved by one of these enzymes (-5[1])into DAG and IP3, which in turn releases calcium from the ER. The C (10[1])and D types of these (-5[1])enzymes (10[1])break a certain diester bond. (-5[1])For 10 points, (-5[1])name these enzymes (-5[1])that cleave (-5[1])a certain type of lipid found in the cell membrane. ■END■ (10[3]0[13])

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