Round 9: Tossup 1

Along with the kinase CDK4, a proto-oncogene that acts as one of these enzymes is amplified in well-differentiated liposarcomas. The “L” component of the Fanconi anemia core complex acts as one of these enzymes. One of these enzymes is recruited to methionine aminopeptidase-2 by a synthetic peptide designed by Sakamoto et al., who created the first PROTAC. MDM2 is one of these enzymes acting on p53. An F-box protein, Skp1, Cullin, and Rbx1 comprise the SCF family of these proteins, which create K48-type and K63-type linkages. These enzymes contain HECT or RING domains. These enzymes catalyze the formation of an isopeptide bond between a 76-amino-acid protein and a target. (10[1])For 10 points, name these enzymes that target proteins for degradation in the proteasome by tagging them with a protein named for being common in the cell. ■END■

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