Packet 10: Bonus 3

“Divergent” methods for producing these molecules begin each new generation with nucleophilic substitutions like the Michael addition. For 10 points each:
[10h] Name these molecules independently synthesized by Denkewalter, Tomalia, and Newkome in the 1980s. A class of these molecules with repeating amine and amide groups are commercialized under the name Starburst.
ANSWER: dendrimers [or dendrons; accept PAMAM or polyamidoamines or Starburst dendrimers; accept arborols; prompt on polymers]
[10e] Unlike divergent dendrimer synthesis, which starts at the core, convergent synthesis begins by forming these surface modifications. Boc and Fmoc (“F-mock”) act as these groups to prevent undesirable side reactions.
ANSWER: protecting groups
[10m] Recent research on dendrimers as drug delivery agents focuses on their synthesis via this reaction, which uses cyclooctynes in a bioorthogonal approach developed by Carolyn Bertozzi.
ANSWER: Huisgen (“HOUSE-gun”) cycloaddition [or azide–alkyne cycloaddition; accept CuAAC]
<Editors, Chemistry> | S. Playoffs 10 (Editors 10)

HeardPPBE %M %H %
2414.1788%46%8%

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Conversion

TeamOpponentPart 1Part 2Part 3TotalParts
BrownSwarthmore0101020EM
BruinRutgers010010E
Chicago ANorthwestern A0101020EM
Columbia AStanford A1010020HE
GeorgetownIllinois B0000
Georgia Tech BNYU B0101020EM
Illinois ATexas10101030HEM
IndianaUC Berkeley B010010E
MITVanderbilt0000
Maryland BCornell010010E
MichiganGeorgia Tech A010010E
NYU AHarvard0101020EM
Ohio StateJohns Hopkins0101020EM
Penn StateVirginia010010E
PittsburghMinnesota010010E
PurdueNorth Carolina010010E
Stanford BColumbia B0000
Toronto AMaryland A0101020EM
Toronto BBritish Columbia0101020EM
UC Berkeley AVirginia Tech0101020EM
UCFChicago B0101020EM
UCLACambridge0101020EM
WashUGeorgia Tech C010010E
WaterlooNorthwestern B010010E

Summary

TournamentEditionMatchHeardPPBE %M %H %
Main Site2026-04-17✓2414.1788%46%8%