Packet 10: Bonus 3
“Divergent” methods for producing these molecules begin each new generation with nucleophilic substitutions like the Michael addition. For 10 points each:
[10h] Name these molecules independently synthesized by Denkewalter, Tomalia, and Newkome in the 1980s. A class of these molecules with repeating amine and amide groups are commercialized under the name Starburst.
ANSWER: dendrimers [or dendrons; accept PAMAM or polyamidoamines or Starburst dendrimers; accept arborols; prompt on polymers]
[10e] Unlike divergent dendrimer synthesis, which starts at the core, convergent synthesis begins by forming these surface modifications. Boc and Fmoc (“F-mock”) act as these groups to prevent undesirable side reactions.
ANSWER: protecting groups
[10m] Recent research on dendrimers as drug delivery agents focuses on their synthesis via this reaction, which uses cyclooctynes in a bioorthogonal approach developed by Carolyn Bertozzi.
ANSWER: Huisgen (“HOUSE-gun”) cycloaddition [or azide–alkyne cycloaddition; accept CuAAC]
<Editors, Chemistry> | S. Playoffs 10 (Editors 10)
| Heard | PPB | E % | M % | H % |
|---|---|---|---|---|
| 24 | 14.17 | 88% | 46% | 8% |
Conversion
| Team | Opponent | Part 1 | Part 2 | Part 3 | Total | Parts |
|---|---|---|---|---|---|---|
| Brown | Swarthmore | 0 | 10 | 10 | 20 | EM |
| Bruin | Rutgers | 0 | 10 | 0 | 10 | E |
| Chicago A | Northwestern A | 0 | 10 | 10 | 20 | EM |
| Columbia A | Stanford A | 10 | 10 | 0 | 20 | HE |
| Georgetown | Illinois B | 0 | 0 | 0 | 0 | |
| Georgia Tech B | NYU B | 0 | 10 | 10 | 20 | EM |
| Illinois A | Texas | 10 | 10 | 10 | 30 | HEM |
| Indiana | UC Berkeley B | 0 | 10 | 0 | 10 | E |
| MIT | Vanderbilt | 0 | 0 | 0 | 0 | |
| Maryland B | Cornell | 0 | 10 | 0 | 10 | E |
| Michigan | Georgia Tech A | 0 | 10 | 0 | 10 | E |
| NYU A | Harvard | 0 | 10 | 10 | 20 | EM |
| Ohio State | Johns Hopkins | 0 | 10 | 10 | 20 | EM |
| Penn State | Virginia | 0 | 10 | 0 | 10 | E |
| Pittsburgh | Minnesota | 0 | 10 | 0 | 10 | E |
| Purdue | North Carolina | 0 | 10 | 0 | 10 | E |
| Stanford B | Columbia B | 0 | 0 | 0 | 0 | |
| Toronto A | Maryland A | 0 | 10 | 10 | 20 | EM |
| Toronto B | British Columbia | 0 | 10 | 10 | 20 | EM |
| UC Berkeley A | Virginia Tech | 0 | 10 | 10 | 20 | EM |
| UCF | Chicago B | 0 | 10 | 10 | 20 | EM |
| UCLA | Cambridge | 0 | 10 | 10 | 20 | EM |
| WashU | Georgia Tech C | 0 | 10 | 0 | 10 | E |
| Waterloo | Northwestern B | 0 | 10 | 0 | 10 | E |
Summary
| Tournament | Edition | Match | Heard | PPB | E % | M % | H % |
|---|---|---|---|---|---|---|---|
| Main Site | 2026-04-17 | ✓ | 24 | 14.17 | 88% | 46% | 8% |